TRENTON, N.J. — Preliminary research suggesting that some diabetes patients may be injecting medicine that has partially disintegrated is causing concern even as serious questions are raised about the research itself.
바카라사이트 then to pharmacies. The FDA conducts spot checks during the process.
Carter thinks the insulin may have gotten too warm somewhere between the factory and the pharmacy, causing some of the molecules to break apart.
Carter wondered whether his results might help explain why insulin users sometimes find a dose doesn’t work as well as normal. Doctors usually attribute that to patient error: not injecting enough insulin before a meal, not following dietary guidelines, or skipping exercise.
Carter, who had a limited budget for his study, acknowledges that it was too small and that his results may be flawed. He notified Novo Nordisk and Eli Lilly of his results in hopes someone would do a bigger follow-up study.
Insulin makers stand by their products, saying they meet strict government quality regulations. Diabetes experts say there’s little chance that insulin being sold nationwide is so degraded.
“If that were true, then you would have the emergency rooms full with uncontrolled diabetic patients,” said Bernd Meibohm, a pharmaceutical sciences professor and research director at the University of Tennessee College of Pharmacy.
Experts say there are multiple methods of testing insulin concentrations and that Carter’s group used a sophisticated one, known as LCMS for short.
Dr. Richard Ostlund, an endocrinologist and professor who heads a large testing lab at Washington University School of Medicine in St. Louis said that method is typically used for testing insulin levels in blood, not vials. He said that test likely couldn’t detect much of the insulin in the vials because it clusters together there, while in the blood it separates into individual molecules.
He and other experts say diabetics should not change their treatment at all.
“Patients should not do anything different in response to this,” Ostlund said. He noted his lab has tested insulin for various research projects and always found vials contained close to what’s listed on the label.